Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds
نویسندگان
چکیده
Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.
منابع مشابه
Traditional Medicinal Plants for Industrial Application as Natural Food Preservatives
Natural food preservation method refers to application of naturally produced antimicrobial compounds that are obtained from plants, animals and microbes to prevent food spoilages microorganism, proliferation and growth of food borne pathogens in food and foods products. Now it is the time of growing interest of many researchers with the application of these natural antimicrobial compounds as sa...
متن کاملTraditional Medicinal Plants for Industrial Application as Natural Food Preservatives
Natural food preservation method refers to application of naturally produced antimicrobial compounds that are obtained from plants, animals and microbes to prevent food spoilages microorganism, proliferation and growth of food borne pathogens in food and foods products. Now it is the time of growing interest of many researchers with the application of these natural antimicrobial compounds as sa...
متن کاملAntimicrobial Peptides of Innate Immune System as a Suitable Compound for Cancer Treatment and Reduction of its Related Infectious Disease
Application of chemotherapy in cancerous children leads to reduction of immune system efficiency. Therefore, these children are prone to various infectious diseases. The excessive use of antibiotics can bring about antibiotic resistant strains. Hence, it is essential to investigate new therapies for this problem. On the other hand, the emergence of resistance against multiple drugs is a major p...
متن کاملThe Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs.
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike classic antibiotics, they induce very little resistance; (3) they act synergically with conventional antibiotics; (4) they neutralize endotoxins and ...
متن کاملAntifungal peptides: novel therapeutic compounds against emerging pathogens.
The need for safe and effective antifungal agents increases in parallel with the expanding number of immunocompromised patients at risk for invasive fungal infections. The emergence of fungal pathogens resistant to current therapies further compounds the dearth of antifungal agents. Currently available antifungal compounds act on targets also found in mammalian cells (34), which may result in t...
متن کامل